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ToolsSTARSurg Collaborative (2017) Safety of nonsteroidal anti-inflammatory drugs in major gastrointestinal surgery: A prospective, multicenter cohort study. World Journal of Surgery, 41 (1). pp. 47-55. ISSN 0364-2313
Full text not available from this repository.Abstract
Background: Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery. Methods: Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals. Results: From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560). Conclusions: Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 May 2023 16:30 |
| Last Modified: | 25 Sep 2024 17:18 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/91961 |
| DOI: | 10.1007/s00268-016-3727-3 |
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