Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity

Mishra, Atreyee, Djoko, Karrera Y., Lee, Yi-Hsuan, Lord, Rianne M. ORCID: https://orcid.org/0000-0001-9981-129X, Kaul, Grace, Akhir, Abdul, Saxena, Deepanshi, Chopra, Sidharth and Walton, James W. (2023) Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity. Organic & Biomolecular Chemistry, 21 (12). pp. 2539-2544. ISSN 1477-0520

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Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.

Item Type: Article
Additional Information: Funding Information: We acknowledge Durham University GCRF CDT for funding. We acknowledge Dmitry S. Yufit for crystallography and Emily R. Unsworth for ICP-OES. We also acknowledge the UKRI Future Leader Fellow scheme which fund the employment of Yi-Hsuan Lee and Rianne M. Lord at the University of East Anglia.
Uncontrolled Keywords: biochemistry,physical and theoretical chemistry,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School: Faculty of Science > School of Chemistry
UEA Research Groups: Faculty of Science > Research Groups > Chemistry of Materials and Catalysis
Faculty of Science > Research Groups > Chemistry of Life Processes
Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry
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Depositing User: LivePure Connector
Date Deposited: 02 May 2023 08:30
Last Modified: 09 Mar 2024 01:48
URI: https://ueaeprints.uea.ac.uk/id/eprint/91914
DOI: 10.1039/D2OB01224C


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