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Mishra, Atreyee, Djoko, Karrera Y., Lee, Yi-Hsuan, Lord, Rianne M. 
ORCID: https://orcid.org/0000-0001-9981-129X, Kaul, Grace, Akhir, Abdul, Saxena, Deepanshi, Chopra, Sidharth and Walton, James W.
(2023)
Water-soluble copper pyrithione complexes with cytotoxic and antibacterial activity.
Organic & Biomolecular Chemistry, 21 (12).
pp. 2539-2544.
ISSN 1477-0520
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Abstract
Copper Pyrithione, [Cu(PyS)2] has shown excellent biological activity against cancer cells and bacterial cells, however, it has extremely low aqueous solubility, limiting its applicability. Herein, we report a series of PEG-substituted pyrithione copper(II) complexes with significantly increased aqueous solubility. While long PEG chains lead to a decrease in bioactivity, the addition of short PEG chains leads to improved aqueous solubility with retention of activity. One novel complex, [Cu(PyS1)2], has particularly impressive anticancer activity, surpassing that of the parent complex.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: We acknowledge Durham University GCRF CDT for funding. We acknowledge Dmitry S. Yufit for crystallography and Emily R. Unsworth for ICP-OES. We also acknowledge the UKRI Future Leader Fellow scheme which fund the employment of Yi-Hsuan Lee and Rianne M. Lord at the University of East Anglia. |
| Uncontrolled Keywords: | biochemistry,physical and theoretical chemistry,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemistry of Materials and Catalysis Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 May 2023 08:30 |
| Last Modified: | 21 Dec 2024 01:06 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/91914 |
| DOI: | 10.1039/D2OB01224C |
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