Tools
Tools
Moore, Carmel Maria, D'Amore, Angela, Fustolo-Gunnink, Suzanne, Hudson, Cara, Newton, Alice, Santamaria, Beatriz Lopez, Deary, Alison, Hodge, Renate, Hopkins, Valerie, Mora, Ana, Llewelyn, Charlotte, Venkatesh, Vidheya, Khan, Rizwan, Willoughby, Karen, Onland, Wes, Fijnvandraat, Karin, New, Helen V., Clarke, Paul 
ORCID: https://orcid.org/0000-0001-6203-7632, Lopriore, Enrico, Watts, Timothy, Stanworth, Simon and Curley, Anna
and
PlaNeT2 MATISSE Collaborators
(2023)
Two-year outcomes following a randomised platelet transfusion trial in preterm infants.
Archives of Disease in Childhood-Fetal and Neonatal Edition, 108 (5).
pp. 452-457.
ISSN 1359-2998
Preview |
PDF (archdischild-2022-324915.full)
- Published Version
Available under License Creative Commons Attribution. Download (467kB) | Preview |
Abstract
Objective: Assess mortality and neurodevelopmental outcomes at 2 years of corrected age in children who participated in the PlaNeT-2/MATISSE (Platelets for Neonatal Transfusion - 2/Management of Thrombocytopenia in Special Subgroup) study, which reported that a higher platelet transfusion threshold was associated with significantly increased mortality or major bleeding compared to a lower one. Design: Randomised clinical trial, enrolling from June 2011 to August 2017. Follow-up was complete by January 2020. Caregivers were not blinded; however, outcome assessors were blinded to treatment group. Setting: 43 level II/III/IV neonatal intensive care units (NICUs) across UK, Netherlands and Ireland. Patients: 660 infants born at less than 34 weeks' gestation with platelet counts less than 50×109/L. Interventions: Infants were randomised to undergo a platelet transfusion at platelet count thresholds of 50×109/L (higher threshold group) or 25×109/L (lower threshold group). Main outcomes measures: Our prespecified long-term follow-up outcome was a composite of death or neurodevelopmental impairment (developmental delay, cerebral palsy, seizure disorder, profound hearing or vision loss) at 2 years of corrected age. Results: Follow-up data were available for 601 of 653 (92%) eligible participants. Of the 296 infants assigned to the higher threshold group, 147 (50%) died or survived with neurodevelopmental impairment, as compared with 120 (39%) of 305 infants assigned to the lower threshold group (OR 1.54, 95% CI 1.09 to 2.17, p=0.017). Conclusions: Infants randomised to a higher platelet transfusion threshold of 50×109/L compared with 25×109/L had a higher rate of death or significant neurodevelopmental impairment at a corrected age of 2 years. This further supports evidence of harm caused by high prophylactic platelet transfusion thresholds in preterm infants. Trial registration number: ISRCTN87736839.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding: This work was supported by the National Health Service Blood and Transplant Research and Development Committee (reference number BS06/1); Sanquin Research, Amsterdam (grant PPOC-12-012027); Addenbrooke’s Charitable Trust; the Neonatal Breath of Life Fund 9145; the National Institute for Health Research Clinical Research Network; the National Maternity Hospital Foundation and the Health Service Executive. |
| Uncontrolled Keywords: | neonatology,child development,intensive care units,neonatal,birth-weight infants,neonatal intensive-care,necrotizing enterocolitis,survival,intensive care units, neonatal,obstetrics and gynaecology,pediatrics, perinatology, and child health ,/dk/atira/pure/subjectarea/asjc/2700/2729 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 Mar 2023 10:30 |
| Last Modified: | 25 Sep 2024 17:14 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/91652 |
| DOI: | 10.1136/archdischild-2022-324915 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |