Naphthylhydrazone based selective and sensitive chemosensors for Cu2+ and their application in bioimaging

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Anbu, Sellamuthu ORCID: https://orcid.org/0000-0002-7176-330X, Shanmugaraju, Sankarasekaran, Ravishankaran, Rajendran, Karande, Anjali A. and Mukherjee, Partha Sarathi (2012) Naphthylhydrazone based selective and sensitive chemosensors for Cu2+ and their application in bioimaging. Dalton Transactions, 41 (43). pp. 13330-13337. ISSN 1477-9226

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Abstract

Two new hydroxynaphthyl-hydrazone based fluorogenic chemosensors R11111 and R22222 have been synthesized by Schiff base condensation of Tris(4-formylphenyl)amine with 1-hydroxynaphthalene-2-hydrazide and 1-hydroxynaphthalene-2-carbohydrazone, respectively. They are examined as highly selective and sensitive receptors for Cu2+ ions in aqueous medium. Electronic absorption as well as fluorescence titration studies of receptors R11111 and R22222 with different metal cations in H2O/CH3CN medium showed highly selective and very rapid (<2 min) binding affinity towards Cu2+ ions even in the presence of other commonly coexisting metal ions such as Na+, K+, Mg2+, Ca2+, Mn2+, Fe2+, Co2+, Ni2+, Zn2+, Cd2+ and Hg2+. Quantification of the fluorescence titration analysis indicated that these newly synthesized receptors (R11111 and R22222) can indicate the presence of Cu2+ ions even at very low concentrations of 598 and 676 ppt, respectively. In addition, the propensity of these receptors as bio-imaging fluorescent probes to detect Cu2+ ions in human cervical HeLa cancer cell lines and their cytotoxicity against HeLa cells have been investigated.

Item Type: Article
Faculty \ School: Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 20 Feb 2023 17:30
Last Modified: 30 Jan 2024 03:32
URI: https://ueaeprints.uea.ac.uk/id/eprint/91223
DOI: 10.1039/c2dt31335a

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