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Sellamuthu, Anbu 
ORCID: https://orcid.org/0000-0002-7176-330X, Asaithambi, Killivalavan, Alegria, Elisabete C B A, Mathan, Ganesan and Kandaswamy, Muthusamy
(2013)
Effect of 1,10-phenanthroline on DNA binding, DNA cleavage, cytotoxic and lactate dehydrogenase inhibition properties of Robson type macrocyclic dicopper(II) complex.
Journal of Coordination Chemistry, 66 (22).
pp. 3989-4003.
ISSN 0095-8972
Abstract
DNA targeting macrocyclic dicopper(II) complex, [Cu2L(H2O)2](phen)2(ClO4)2 (L = μ-11,23-dimethyl-3,7,15,19-tetraazatricyclo-[19.3.1.19,13,21] he p t a c o s a-1(24), 2, 7, 9, 11, 13(26), 14, 19, 21(25), 22-decaene-25,26-diol) (2), has been synthesized and characterized. This has been synthesized by reacting a Robson type macrocyclic precursor dicopper(II) complex [Cu2L(H2O)2](ClO4)2 (1) and 1,10-phenanthroline in ethanol. Solution ESR, electronic, and ESI-MS spectral studies suggest that 1,10-phenanthroline replaces coordinated water in 1, giving 2. The influence of the phenanthroline on DNA binding, cleavage, and anticancer properties of 2 have been investigated. Complex 2 displays better DNA binding and cleavage than 1. The dicopper(II) complexes 1 and 2 show cytotoxicity in human cervical HeLa cancer cells, giving IC50 values of 79.41 and 15.82 μM, respectively. Antiproliferative properties of 1 and 2 were confirmed by Trypan Blue exclusive assay and lactate dehydrogenase enzyme level in HeLa cancer cell lysate and content media.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Science > School of Chemistry |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Feb 2023 15:30 |
| Last Modified: | 30 Jan 2024 03:32 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/91210 |
| DOI: | 10.1080/00958972.2013.858136 |
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