Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins

Sargent, Frank, Berks, Ben C. and Palmer, Tracy (2006) Pathfinders and trailblazers: a prokaryotic targeting system for transport of folded proteins. FEMS Microbiology Letters, 254 (2). 198–207. ISSN 0378-1097

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Abstract

The twin-arginine (Tat) protein translocase is a highly unusual protein transport machine that is dedicated to the movement of folded proteins across the bacterial cytoplasmic membrane. Proteins are targeted to the Tat pathway by means of N-terminal signal peptides harbouring a distinctive twin-arginine motif. In this minireview, we describe our current knowledge of the Tat system, paying particular attention to the function of the TatA protein and to the often overlooked step of signal peptide cleavage.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
Depositing User:	LivePure Connector
Date Deposited:	16 Feb 2023 10:31
Last Modified:	16 Feb 2023 10:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/91152
DOI:	10.1111/j.1574-6968.2005.00049.x

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