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Phillips, Lucy, Thomson, Ross, Coleman-Haynes, Tom, Cooper, Sue, Naughton, Felix, McDaid, Lisa 
ORCID: https://orcid.org/0000-0001-5032-2380, Emery, Joanne ORCID: https://orcid.org/0000-0002-8915-7033 and Coleman, Tim
(2023)
Developing a taxonomy to describe offspring outcomes in studies involving pregnant mammals’ exposure to non-tobacco nicotine: A systematic scoping review.
PLoS One, 18 (2).
ISSN 1932-6203
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Abstract
Introduction: Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. Preclinical studies of nicotine exposure to pregnant mammals could indicate how nicotine may adversely affect the developing fetus. As a first step towards summarising this literature, we undertook a systematic scoping review to determine the number and nature of offspring outcomes studied. Methods: We searched MEDLINE and EMBASE databases for papers reporting empirical data on offspring outcomes following nicotine exposure to pregnant non-human mammals. We excluded studies that investigated exposure to only smoking, e-cigarettes, nicotine vaccines, or studies with no ‘nicotine only’ group. We developed a draft taxonomy and using this, described and quantified outcomes reported. Results: We identified 476 studies, which reported 729 offspring outcomes. The draft taxonomy classified outcomes as being measured in i) whole animals, ii) body systems and iii) ‘other’. Body system outcomes were further categorised as being functional changes, or changes at macroscopic or cellular levels. The most frequently used outcomes were those detecting changes in the brain (n = 265), physical parameters measured in whole animals (n = 122) and any respiratory system changes (n = 97). Conclusions: This scoping review quantifies the nature and frequency of outcomes used in preclinical studies investigating the potential impacts of nicotine administration in pregnancy on offspring. Systematic reviews of studies investigating outcomes involving animal brains, respiratory system, or ‘whole animal’ outcomes may have greatest potential for further advancing knowledge regarding impacts of gestational nicotine exposure on offspring.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding: This project was funded through a National Institute for Health Research (NIHR) Programme Grants for Applied Research (Programme number RP‐PG‐0615‐20003). Tim Coleman is a National Institute for Health Research (NIHR) Senior Investigator. The views expressed in this manuscript are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. |
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Behavioural and Implementation Science Faculty of Medicine and Health Sciences > Research Groups > Health Promotion Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 09 Feb 2023 17:30 |
| Last Modified: | 19 Oct 2023 03:33 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/91097 |
| DOI: | 10.1371/journal.pone.0280805 |
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