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Shannon, Oliver M., Ranson, Janice M., Gregory, Sarah, Macpherson, Helen, Milte, Catherine, Lentjes, Marleen, Mulligan, Angela, McEvoy, Claire, Griffiths, Alex, Matu, Jamie, Hill, Tom R., Adamson, Ashley, Servo, Mario, Minihane, Anne-Marie 
ORCID: https://orcid.org/0000-0001-9042-4226, Muniz-Tererra, Graciela, Ritchie, Craig, Mathers, John C., Llewellyn, David J. and Stevenson, Emma
(2023)
Mediterranean diet adherence is associated with lower dementia risk, independent of genetic predisposition: Findings from the UK Biobank prospective cohort study.
BMC Medicine, 21.
ISSN 1741-7015
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Abstract
BACKGROUND: The identification of effective dementia prevention strategies is a major public health priority, due to the enormous and growing societal cost of this condition. Consumption of a Mediterranean diet (MedDiet) has been proposed to reduce dementia risk. However, current evidence is inconclusive and is typically derived from small cohorts with limited dementia cases. Additionally, few studies have explored the interaction between diet and genetic risk of dementia. METHODS: We used Cox proportional hazard regression models to explore the associations between MedDiet adherence, defined using two different scores (MedDiet Adherence Screener [MEDAS] continuous and Mediterranean diet Pyramid [PYRAMID] scores), and incident all-cause dementia risk in 60298 participants from UK Biobank, followed for an average 9.1 years. The interaction between diet and polygenic risk for dementia was also tested. RESULTS: Higher MedDiet adherence was associated with lower dementia risk (MEDAS continuous: HR=0.77, 95% CI=0.65-0.91; PYRAMID: HR=0.86, 95% CI=0.73-1.02 for highest versus lowest tertiles). There was no significant interaction between MedDiet adherence defined by the MEDAS continuous and PYRAMID scores and polygenic risk for dementia. CONCLUSIONS: Higher adherence to a MedDiet was associated with lower dementia risk, independent of genetic risk, underlining the importance of diet in dementia prevention interventions.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding: This research was conducted as part of the NuBrain consortium, which is funded by the UK Nutrition Research Partnership (UK NRP), an initiative supported by the Medical Research Council (MRC), Biotechnology and Biological Sciences Research Council (BBSRC) and the National Institute for Health Research (NIHR) (MR/T001852/1). |
| Uncontrolled Keywords: | alzheimer’s,dementia,genetics,mediterranean diet,polygenic risk,risk factors,uk biobank,medicine(all),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Feb 2023 17:30 |
| Last Modified: | 25 Sep 2024 17:08 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/90968 |
| DOI: | 10.1186/s12916-023-02772-3 |
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