Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study

Dong, Catherine, Chan, Simon S. M., Jantchou, Prevost, Racine, Antoine, Oldenburg, Bas, Weiderpass, Elisabete, Heath, Alicia K., Tong, Tammy Y. N., Tjønneland, Anne, Kyrø, Cecilie, Bueno de Mesquita, Bas, Kaaks, Rudolf, Katzke, Verena A., Bergman, Manuela M., Boeing, Heiner, Palli, Domenico, Masala, Giovanna, Tumino, Rosario, Sacerdote, Carlotta, Colorado-Yohar, Sandra M., Sánchez, Maria-Jose, Grip, Olof, Lindgren, Stefan, Luben, Robert, Huybrechts, Inge, Gunter, Marc J., Mahamat-Saleh, Yahya, Boutron-Ruault, Marie-Christine and Carbonnel, Franck (2022) Meat intake is associated with a higher risk of ulcerative colitis in a large European prospective cohort study. Journal of Crohn's & Colitis, 16 (8). pp. 1187-1196. ISSN 1873-9946

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Abstract

BACKGROUND AND AIMS: We aimed to investigate the association between protein intake and risk of inflammatory bowel disease [IBD] in the European Prospective Investigation into Cancer and Nutrition. METHODS: A total of 413 593 participants from eight European countries were included. Dietary data were collected at baseline from validated food frequency questionnaires. Dietary data were calibrated to correct errors in measures related to each country-specific questionnaire. Associations between proteins [total, animal, and vegetable] or food sources of animal proteins, and IBD risk were estimated by Cox proportional hazard models. RESULTS: After a mean follow-up of 16 years, 177 patients with Crohn's disease [CD] and 418 with ulcerative colitis [UC], were identified. There was no association between total protein, animal protein, or vegetable protein intakes and CD or UC risks. Total meat and red meat intakes were associated with UC risk (hazard ratio [HR] for the 4th vs 1st quartile = 1.40, 95% confidence interval [CI] = 0.99-1.98, p-trend = 0.01; and 1.61, 95% CI = 1.10-2.36, p-trend = 0.007, respectively]. There was no association between other food sources of animal protein [processed meat, fish, shellfish, eggs, poultry] and UC. We found no association between food sources of animal proteins and CD risk. CONCLUSIONS: Meat and red meat consumptions are associated with higher risks of UC. These results support dietary counselling of low meat intake in people at high-risk of IBD.

Item Type:	Article
Uncontrolled Keywords:	diet,inflammatory bowel disease,meat,gastroenterology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2715
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?... https://spiral.imperial.ac.uk/handle/100... https://discovery.ucl.ac.uk/id/eprint/10...
Depositing User:	LivePure Connector
Date Deposited:	06 Jan 2023 15:34
Last Modified:	25 Sep 2024 17:03
URI:	https://ueaeprints.uea.ac.uk/id/eprint/90460
DOI:	10.1093/ecco-jcc/jjac054

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