Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain

Basu, B., Correa de Sampaio, P., Mohammed, H., Fogarasi, M., Corrie, P., Watkins, N. A., Smethurst, P. A., English, W. R. ORCID: https://orcid.org/0000-0003-3024-2441, Ouwehand, W. H. and Murphy, G. (2012) Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domain. International Journal of Biochemistry & Cell Biology, 44 (2). pp. 393-403. ISSN 1357-2725

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Abstract

The membrane associated MMP, MT1-MMP, is a critical pericellular protease involved in tumour cell invasion and angiogenesis and is highly up-regulated in numerous human cancers. It therefore represents an exciting new therapeutic cancer-specific target. We have generated recombinant human scFv antibodies against the non-catalytic, hemopexin domain of MT1-MMP that modulate its interactions with collagen. One of these is an effective inhibitor of the invasive capacity of cancer cells and of angiogenesis in model systems. This demonstrates that targeting sites outside the catalytic domain presents a potential novel approach to proteinase inhibition that could have applications in cancer therapeutics.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Depositing User:	LivePure Connector
Date Deposited:	15 Dec 2022 11:31
Last Modified:	19 Oct 2023 03:30
URI:	https://ueaeprints.uea.ac.uk/id/eprint/90208
DOI:	10.1016/j.biocel.2011.11.015

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