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Bradshaw, Lucy E., Wyatt, Laura A., Brown, Sara J., Haines, Rachel H., Montgomery, Alan A., Perkin, Michael R., Lawton, Sandra, Sach, Tracey H. 
ORCID: https://orcid.org/0000-0002-8098-9220, Chalmers, Joanne R., Ridd, Matthew J., Flohr, Carsten, Brooks, Joanne, Swinden, Richard, Mitchell, Eleanor J., Tarr, Stella, Jay, Nicola, Thomas, Kim S., Allen, Hilary, Cork, Michael J., Kelleher, Maeve M., Simpson, Eric l., Lartey, Stella T. ORCID: https://orcid.org/0000-0001-9519-7886, Davies-Jones, Susan, Boyle, Robert J. and Williams, Hywel C.
(2023)
Emollients for prevention of atopic dermatitis: 5-year findings from the BEEP randomized trial.
Allergy, 78 (4).
pp. 995-1006.
ISSN 0105-4538
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Abstract
Background: The effectiveness of emollients for preventing atopic dermatitis/eczema is controversial. The Barrier Enhancement for Eczema Prevention trial evaluated the effects of daily emollients during the first year of life on atopic dermatitis and atopic conditions to age 5 years. Methods: 1394 term infants with a family history of atopic disease were randomized (1:1) to daily emollient plus standard skin-care advice (693 emollient group) or standard skin-care advice alone (701 controls). Long-term follow-up at ages 3, 4 and 5 years was via parental questionnaires. Main outcomes were parental report of a clinical diagnosis of atopic dermatitis and food allergy. Results: Parents reported more frequent moisturizer application in the emollient group through to 5 years. A clinical diagnosis of atopic dermatitis between 12 and 60 months was reported for 188/608 (31%) in the emollient group and 178/631 (28%) in the control group (adjusted relative risk 1.10, 95% confidence interval 0.93 to 1.30). Although more parents in the emollient group reported food reactions in the previous year at 3 and 4 years, cumulative incidence of doctor-diagnosed food allergy by 5 years was similar between groups (92/609 [15%] emollients and 87/632 [14%] controls, adjusted relative risk 1.11, 95% confidence interval 0.84 to 1.45). Findings were similar for cumulative incidence of asthma and hay fever. Conclusions: Daily emollient application during the first year of life does not prevent atopic dermatitis, food allergy, asthma or hay fever.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment (HTA) programme (project number 12/67/12). Data Availability Statement: The data that support the findings of this study are available from the corresponding author upon reasonable request. Access to the data will be subject to review of a data sharing and use request (available from ctu@nottingham.ac.uk) by a committee including the CI and sponsor, and will only be granted upon receipt of a data sharing and use agreement. Any data shared will be pseudoanonymised which may impact on the reproducibility of published analyses. The study protocol, statistical analysis plan and health economics analysis plan are available on the trial website: https://www.nottingham.ac.uk/research/groups/cebd/projects/1eczema/beep-maintrial.aspx. |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Dec 2022 04:00 |
| Last Modified: | 05 Apr 2024 11:31 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/90116 |
| DOI: | 10.1111/all.15555 |
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