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Marchal, Clemence, Pai, Hsuan, Kamoun, Sophien 
ORCID: https://orcid.org/0000-0002-0290-0315 and Kourelis, Jiorgos ORCID: https://orcid.org/0000-0002-9007-1333
(2022)
Emerging principles in the design of bioengineered made-to-order plant immune receptors.
Current Opinion in Plant Biology, 70.
ISSN 1369-5266
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Abstract
Crop yield and global food security are under constant threat from plant pathogens with the potential to cause epidemics. Traditional breeding for disease resistance can be too slow to counteract these emerging threats, resulting in the need to retool the plant immune system using bioengineered made-to-order immune receptors. Efforts to engineer immune receptors have focused primarily on nucleotide-binding domain and leucine-rich repeat (NLR) immune receptors and proof-of-principles studies. Based upon a near-exhaustive literature search of previously engineered plant immune systems we distil five emerging principles in the design of bioengineered made-to-order plant NLRs and describe approaches based on other components. These emerging principles are anticipated to assist the functional understanding of plant immune receptors, as well as bioengineering novel disease resistance specificities.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding information: This work has been supported by the Gatsby Charitable Foundation (SK), Biotechnology and Biological Sciences Research Council (BBSRC) (SK), Rijk Zwaan Netherlands (HP, SK), Groupe Limagrain (CM, SK), and BASF Plant Science (JK, SK). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. |
| Uncontrolled Keywords: | nb-lrr,nbs-lrr,nlr,nlr engineering,nlr-id,synthetic biology,plant science ,/dk/atira/pure/subjectarea/asjc/1100/1110 |
| Faculty \ School: | Faculty of Science > The Sainsbury Laboratory Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Plant Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 22 Nov 2022 12:30 |
| Last Modified: | 09 Mar 2024 07:30 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/89949 |
| DOI: | 10.1016/j.pbi.2022.102311 |
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