The relationship between perceived control, depression, and medication adherence in people with Parkinson’s Disease

Zarotti, Nicolo (2022) The relationship between perceived control, depression, and medication adherence in people with Parkinson’s Disease. Doctoral thesis, University of East Anglia.

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Background: Parkinson’s is an incurable neurodegenerative condition typically treated with highly complex medication regimens. However, medication adherence in people with Parkinson’s (PwP) is problematic, with up to 70% of PwP reported non-adherent to prescribed medication regimens. Research suggests medication adherence in PwP may be influenced by psychological factors, such as depression and subconstructs of perceived control.

Methods: This thesis portfolio aimed to address some of the gaps in the current literature around perceived control, depression, and medication adherence in PwP. First, a scoping review was carried out to identify types of psychosocial interventions for PwP which measured perceptions of control as an outcome. Second, an online cross-sectional survey was conducted to investigate the role of perceived control as a predictor of medication adherence in 1210 PwP from 15 English-speaking countries.

Results: The scoping review identified 12 eligible studies investigating four categories of psychosocial interventions. Mixed findings were found for cognitive, educational, and physical interventions, while positive evidence was observed for a mindfulness-based lifestyle programme. In the survey, perceived control accounted for slightly greater variance in medication adherence than medication variables, and internal and external dimensions of locus of control emerged as independent predictors. Unexpectedly, depression shared no significant relationship with medication adherence.

Conclusions: In PwP, perceived control may exert a more significant impact on medication adherence than depression or medication-related factors. However, the literature on psychosocial interventions affecting perceived control in this population is still in its infancy. Directions for future research and implications for clinical psychology practice are discussed.

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Chris White
Date Deposited: 16 Nov 2022 12:40
Last Modified: 16 Nov 2022 12:40

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