Into the multiverse: Advances in single-cell multiomic profiling

Ogbeide, Silvia, Giannese, Francesca, Mincarelli, Laura and Macaulay, Iain C. (2022) Into the multiverse: Advances in single-cell multiomic profiling. Trends in Genetics, 38 (8). pp. 831-843. ISSN 0168-9525

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Single-cell transcriptomic approaches have revolutionised the study of complex biological systems, with the routine measurement of gene expression in thousands of cells enabling construction of whole-organism cell atlases. However, the transcriptome is just one layer amongst many that coordinate to define cell type and state and, ultimately, function. In parallel with the widespread uptake of single-cell RNA-seq (scRNA-seq), there has been a rapid emergence of methods that enable multiomic profiling of individual cells, enabling parallel measurement of intercellular heterogeneity in the genome, epigenome, transcriptome, and proteomes. Linking measurements from each of these layers has the potential to reveal regulatory and functional mechanisms underlying cell behaviour in healthy development and disease.

Item Type: Article
Additional Information: Funding Information: The authors acknowledge support from an AIRC/CRUK/FC AECC Accelerator Award 'Single Cell Cancer Evolution in the Clinic', A26815 (AIRC number program 2279), Biotechnology and Biological Sciences Research Council (BBSRC), part of UK Research and Innovation, Core Capability Grant (BB/CCG1720/1) and the National Capability in Genomics and Single Cell Analysis (BBS/E/T/000PR9816) and the BBSRC Core Strategic Programme Grant (Genomes to Food Security) BB/CSP1720/1. I.C.M. is supported by a BBSRC New Investigator Grant (BB/P022073/1).
Uncontrolled Keywords: epigenomics,genomics,multiomics,single-cell,transcriptomics,genetics ,/dk/atira/pure/subjectarea/asjc/1300/1311
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 04 Nov 2022 17:30
Last Modified: 04 Nov 2022 17:30
DOI: 10.1016/j.tig.2022.03.015


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