Tools
Tools
Sokhal, Balamrit Singh, Matetić, Andrija, Paul, Timir K., Velagapudi, Poonam, Lambrinou, Ekaterini, Figtree, Gemma A., Rashid, Muhammad, Moledina, Saadiq, Vassiliou, Vassilios S. 
ORCID: https://orcid.org/0000-0002-4005-7752, Mallen, Christian and Mamas, Mamas A.
(2023)
Management and outcomes of patients admitted with type 2 myocardial infarction with and without standard modifiable risk factors.
International Journal of Cardiology, 371.
pp. 391-396.
ISSN 1874-1754
Preview |
PDF (1-s2.0-S0167527322013870-main)
- Published Version
Available under License Creative Commons Attribution. Download (636kB) | Preview |
Abstract
Background: Whilst it is known patients without standard modifiable cardiovascular risk factors (SMuRF; hypertension, diabetes, hypercholesterolaemia, smoking) have worse outcomes in Type 1 acute myocardial infarction (AMI), the relationship between type 2 AMI (T2AMI) and outcomes in patients with and without SMuRF is unknown. This study aimed to determine the prevalence, characteristics and clinical outcomes of patients hospitalised with T2AMI based on the presence of SMuRF. Methods: Using the National Inpatient Sample, all hospitalizations with a primary discharge diagnosis of T2AMI were stratified according to SMuRF status (SMuRF and SMURF-less). Primary outcome was all-cause mortality while secondary outcomes were major adverse cardiovascular and cerebrovascular events (MACCE), major bleeding and ischemic stroke. Multivariable logistic regression was used to determine adjusted odds ratios (aOR) with 95% confidence intervals (95% CI). Results: Among 17,595 included hospitalizations, 1345 (7.6%) were SMuRF-less and 16,250 (92.4%) were SMuRF. On adjusted analysis, SMuRF-less patients had increased odds of all-cause mortality (aOR 2.43, 95% CI 1.83 to 3.23), MACCE (aOR 2.32, 95% CI 1.79 to 2.90) and ischaemic stroke (aOR 2.57, 95% CI 1.56 to 4.24) compared to their SMuRF counterparts. Secondary diagnoses among both cohorts were similar, with respiratory disorders most prevalent followed by cardiovascular and renal disorders. Conclusions: T2AMI in the absence of SMuRF was associated with worse in-hospital outcomes compared to SMuRF-less patients. There was no SMuRF-based difference in the secondary diagnoses with the most common being respiratory, cardiovascular, and renal disorders. Further studies are warranted to improve overall care and outcomes of SMuRF-less patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 26 Sep 2022 11:33 |
| Last Modified: | 19 Oct 2023 03:26 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/88644 |
| DOI: | 10.1016/j.ijcard.2022.09.037 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |