Biotechnological advances in Bacterial Microcompartment technology

Lee, Matthew J., Palmer, David J. and Warren, Martin J. ORCID: https://orcid.org/0000-0002-6028-6456 (2019) Biotechnological advances in Bacterial Microcompartment technology. Trends in Biotechnology, 37 (3). pp. 325-336. ISSN 0167-7799

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Abstract

Bacterial microcompartments (BMCs) represent proteinaceous macromolecular nanobioreactors that are found in a broad range of bacteria, and which are associated with either anabolic or catabolic processes. They consist of a semipermeable outer shell that packages a central metabolic enzyme or pathway, providing both enhanced flux and protection against toxic intermediates. Recombinant production of BMCs has led to their repurposing with the incorporation of altogether new pathways. Deconstructing BMCs into their component parts has shown that some individual shell proteins self-associate into filaments that can be further modified into a cytoplasmic scaffold, or cytoscaffold, to which enzymes/proteins can be targeted. BMCs therefore represent a modular system that is highly suited for engineering biological systems for useful purposes.

Item Type:	Article
Additional Information:	Funding Information: We are grateful to the Biotechnology and Biological Sciences Research Council of the UK for a strategic LoLa Award ( BB/M002969/1 ). Publisher Copyright: © 2018 Elsevier Ltd
Uncontrolled Keywords:	bacterial microcompartments,metabolic engineering,metabolism,protein engineering,shell,synthetic biology,biotechnology,bioengineering ,/dk/atira/pure/subjectarea/asjc/1300/1305
Faculty \ School:	Faculty of Science
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	20 Sep 2022 14:30
Last Modified:	24 Oct 2022 06:52
URI:	https://ueaeprints.uea.ac.uk/id/eprint/88479
DOI:	10.1016/j.tibtech.2018.08.006

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