Evolutionary analysis of the female-specific avian W chromosome

Smeds, Linnéa, Warmuth, Vera, Bolivar, Paulina, Uebbing, Severin, Burri, Reto, Suh, Alexander ORCID: https://orcid.org/0000-0002-8979-9992, Nater, Alexander, Bureš, Stanislav, Garamszegi, Laszlo Z., Hogner, Silje, Moreno, Juan, Qvarnström, Anna, Ruzic, Milan, Sæther, Stein Are, Sætre, Glenn Peter, Török, Janos and Ellegren, Hans (2015) Evolutionary analysis of the female-specific avian W chromosome. Nature Communications, 6. ISSN 2041-1723

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Abstract

The typically repetitive nature of the sex-limited chromosome means that it is often excluded from or poorly covered in genome assemblies, hindering studies of evolutionary and population genomic processes in non-recombining chromosomes. Here, we present a draft assembly of the non-recombining region of the collared flycatcher W chromosome, containing 46 genes without evidence of female-specific functional differentiation. Survival of genes during W chromosome degeneration has been highly non-random and expression data suggest that this can be attributed to selection for maintaining gene dose and ancestral expression levels of essential genes. Re-sequencing of large population samples revealed dramatically reduced levels of within-species diversity and elevated rates of between-species differentiation (lineage sorting), consistent with low effective population size. Concordance between W chromosome and mitochondrial DNA phylogenetic trees demonstrates evolutionary stable matrilineal inheritance of this nuclear-cytonuclear pair of chromosomes. Our results show both commonalities and differences between W chromosome and Y chromosome evolution.

Item Type: Article
Additional Information: Funding Information: This work was supported by an Advanced Investigator Grant (NEXTGENMOLECOL) from the European Research Council, a Wallenberg Scholar Award from the Knut and Alice Wallenberg Foundation and from the Swedish Research Council (2007-8731, 2010-5650 and 2013-8271). Computations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX). Publisher Copyright: © 2015 Macmillan Publishers Limited. All rights reserved.
Uncontrolled Keywords: chemistry(all),biochemistry, genetics and molecular biology(all),physics and astronomy(all) ,/dk/atira/pure/subjectarea/asjc/1600
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 16 Sep 2022 15:36
Last Modified: 23 Sep 2022 16:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/88417
DOI: 10.1038/ncomms8330

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