Evolutionary analysis of the female-specific avian W chromosome

Smeds, Linnéa, Warmuth, Vera, Bolivar, Paulina, Uebbing, Severin, Burri, Reto, Suh, Alexander, Nater, Alexander, Bureš, Stanislav, Garamszegi, Laszlo Z., Hogner, Silje, Moreno, Juan, Qvarnström, Anna, Ruzic, Milan, Sæther, Stein Are, Sætre, Glenn Peter, Török, Janos and Ellegren, Hans (2015) Evolutionary analysis of the female-specific avian W chromosome. Nature Communications, 6. ISSN 2041-1723

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Abstract

The typically repetitive nature of the sex-limited chromosome means that it is often excluded from or poorly covered in genome assemblies, hindering studies of evolutionary and population genomic processes in non-recombining chromosomes. Here, we present a draft assembly of the non-recombining region of the collared flycatcher W chromosome, containing 46 genes without evidence of female-specific functional differentiation. Survival of genes during W chromosome degeneration has been highly non-random and expression data suggest that this can be attributed to selection for maintaining gene dose and ancestral expression levels of essential genes. Re-sequencing of large population samples revealed dramatically reduced levels of within-species diversity and elevated rates of between-species differentiation (lineage sorting), consistent with low effective population size. Concordance between W chromosome and mitochondrial DNA phylogenetic trees demonstrates evolutionary stable matrilineal inheritance of this nuclear-cytonuclear pair of chromosomes. Our results show both commonalities and differences between W chromosome and Y chromosome evolution.

Item Type:	Article
Additional Information:	Funding Information: This work was supported by an Advanced Investigator Grant (NEXTGENMOLECOL) from the European Research Council, a Wallenberg Scholar Award from the Knut and Alice Wallenberg Foundation and from the Swedish Research Council (2007-8731, 2010-5650 and 2013-8271). Computations were performed on resources provided by the Swedish National Infrastructure for Computing (SNIC) through Uppsala Multidisciplinary Center for Advanced Computational Science (UPPMAX). Publisher Copyright: © 2015 Macmillan Publishers Limited. All rights reserved.
Uncontrolled Keywords:	chemistry(all),biochemistry, genetics and molecular biology(all),physics and astronomy(all) ,/dk/atira/pure/subjectarea/asjc/1600
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	16 Sep 2022 15:36
Last Modified:	06 Feb 2025 10:57
URI:	https://ueaeprints.uea.ac.uk/id/eprint/88417
DOI:	10.1038/ncomms8330

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