The Specific Requirements for CR1 Retrotransposition Explain the Scarcity of Retrogenes in Birds

Suh, Alexander ORCID: https://orcid.org/0000-0002-8979-9992 (2015) The Specific Requirements for CR1 Retrotransposition Explain the Scarcity of Retrogenes in Birds. Journal of Molecular Evolution, 81 (1-2). pp. 18-20. ISSN 0022-2844

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Abstract

Chicken repeat 1 (CR1) retroposons are the most abundant superfamily of transposable elements in the genomes of birds, crocodilians, and turtles. However, CR1 mobilization remains poorly understood. In this article, I document that the diverse CR1 lineages of land vertebrates share a highly conserved hairpin structure and an octamer microsatellite motif at their very 3′ ends. Together with the presence of these same motifs in the tails of CR1-mobilized short interspersed elements, this suggests that the minimum requirement for CR1 transcript recognition and retrotransposition is a complex >50-nt structure. Such a highly specific recognition sequence readily explains why CR1-dominated genomes generally contain very few retrogenes. Conversely, the mammalian richness in retrogenes results from CR1 extinction in their early evolution and subsequent establishment of L1 dominance.

Item Type: Article
Additional Information: Publisher Copyright: © 2015, Springer Science+Business Media New York.
Uncontrolled Keywords: chicken repeat 1,land vertebrates,long interspersed element,microsatellite,retrogene,retrotransposition,ecology, evolution, behavior and systematics,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School: Faculty of Science > School of Biological Sciences
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 16 Sep 2022 15:35
Last Modified: 23 Sep 2022 16:33
URI: https://ueaeprints.uea.ac.uk/id/eprint/88415
DOI: 10.1007/s00239-015-9692-x

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