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Suh, Alexander 
ORCID: https://orcid.org/0000-0002-8979-9992
(2015)
The specific requirements for CR1 retrotransposition explain the scarcity of retrogenes in birds.
Journal of Molecular Evolution, 81 (1-2).
pp. 18-20.
ISSN 0022-2844
Abstract
Chicken repeat 1 (CR1) retroposons are the most abundant superfamily of transposable elements in the genomes of birds, crocodilians, and turtles. However, CR1 mobilization remains poorly understood. In this article, I document that the diverse CR1 lineages of land vertebrates share a highly conserved hairpin structure and an octamer microsatellite motif at their very 3′ ends. Together with the presence of these same motifs in the tails of CR1-mobilized short interspersed elements, this suggests that the minimum requirement for CR1 transcript recognition and retrotransposition is a complex >50-nt structure. Such a highly specific recognition sequence readily explains why CR1-dominated genomes generally contain very few retrogenes. Conversely, the mammalian richness in retrogenes results from CR1 extinction in their early evolution and subsequent establishment of L1 dominance.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher Copyright: © 2015, Springer Science+Business Media New York. |
| Uncontrolled Keywords: | chicken repeat 1,land vertebrates,long interspersed element,microsatellite,retrogene,retrotransposition,ecology, evolution, behavior and systematics,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 16 Sep 2022 15:35 |
| Last Modified: | 07 Apr 2024 00:51 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/88415 |
| DOI: | 10.1007/s00239-015-9692-x |
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