The specific requirements for CR1 retrotransposition explain the scarcity of retrogenes in birds

Suh, Alexander ORCID: https://orcid.org/0000-0002-8979-9992 (2015) The specific requirements for CR1 retrotransposition explain the scarcity of retrogenes in birds. Journal of Molecular Evolution, 81 (1-2). pp. 18-20. ISSN 0022-2844

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Abstract

Chicken repeat 1 (CR1) retroposons are the most abundant superfamily of transposable elements in the genomes of birds, crocodilians, and turtles. However, CR1 mobilization remains poorly understood. In this article, I document that the diverse CR1 lineages of land vertebrates share a highly conserved hairpin structure and an octamer microsatellite motif at their very 3′ ends. Together with the presence of these same motifs in the tails of CR1-mobilized short interspersed elements, this suggests that the minimum requirement for CR1 transcript recognition and retrotransposition is a complex >50-nt structure. Such a highly specific recognition sequence readily explains why CR1-dominated genomes generally contain very few retrogenes. Conversely, the mammalian richness in retrogenes results from CR1 extinction in their early evolution and subsequent establishment of L1 dominance.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2015, Springer Science+Business Media New York.
Uncontrolled Keywords:	chicken repeat 1,land vertebrates,long interspersed element,microsatellite,retrogene,retrotransposition,ecology, evolution, behavior and systematics,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	16 Sep 2022 15:35
Last Modified:	25 Sep 2024 16:47
URI:	https://ueaeprints.uea.ac.uk/id/eprint/88415
DOI:	10.1007/s00239-015-9692-x

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