The specific requirements for CR1 retrotransposition explain the scarcity of retrogenes in birds

Suh, Alexander (2015) The specific requirements for CR1 retrotransposition explain the scarcity of retrogenes in birds. Journal of Molecular Evolution, 81 (1-2). pp. 18-20. ISSN 0022-2844

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Abstract

Chicken repeat 1 (CR1) retroposons are the most abundant superfamily of transposable elements in the genomes of birds, crocodilians, and turtles. However, CR1 mobilization remains poorly understood. In this article, I document that the diverse CR1 lineages of land vertebrates share a highly conserved hairpin structure and an octamer microsatellite motif at their very 3′ ends. Together with the presence of these same motifs in the tails of CR1-mobilized short interspersed elements, this suggests that the minimum requirement for CR1 transcript recognition and retrotransposition is a complex >50-nt structure. Such a highly specific recognition sequence readily explains why CR1-dominated genomes generally contain very few retrogenes. Conversely, the mammalian richness in retrogenes results from CR1 extinction in their early evolution and subsequent establishment of L1 dominance.

Item Type:	Article
Additional Information:	Publisher Copyright: © 2015, Springer Science+Business Media New York.
Uncontrolled Keywords:	chicken repeat 1,land vertebrates,long interspersed element,microsatellite,retrogene,retrotransposition,ecology, evolution, behavior and systematics,molecular biology,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	16 Sep 2022 15:35
Last Modified:	06 Feb 2025 10:57
URI:	https://ueaeprints.uea.ac.uk/id/eprint/88415
DOI:	10.1007/s00239-015-9692-x

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