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Haerty, Wilfried 
ORCID: https://orcid.org/0000-0003-0111-191X and Golding, G. Brian
(2011)
Increased polymorphism near low-complexity sequences across the genomes of Plasmodium falciparum isolates.
Genome Biology and Evolution, 3 (1).
pp. 539-550.
ISSN 1759-6653
Abstract
Low-complexity regions (LCRs) within proteins sequences are often considered to evolve neutrally even though recent studies reported evidence for selection acting on some of them. Because of their widespread distribution among eukaryotes genomes and the potential deleterious effect of expansion/ contraction of some of them in humans, low-complexity sequences are of major interest and numerous studies have attempted to describe their dynamic between genomes as well as the factors correlated to their variation and to assess their selective value. However, due to the scarcity of individual genomes within a species, most of the analyses so far have been performed at the species level with the implicit assumption that the variation both in composition and size within species is too small relative to the between-species divergence to affect the conclusions of the analysis. Here we used the available genomes of 14 Plasmodium falciparum isolates to assess the relationship between low-complexity sequence variation and factors such as nucleotide polymorphism across strains, sequence composition, and protein expression. We report that more than half of the 7,711 low-complexity sequences found within aligned coding sequences are variable in size among strains. Across strains, we observed an increasing density of polymorphic sites toward the LCR boundaries. This observation strongly suggests the joint effects of lowered selective constraints on low-complexity sequences and a mutagenic effect of these simple sequences.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | low complexity sequences,plasmodium falciparum,polymorphism,size variation,ecology, evolution, behavior and systematics,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Sep 2022 14:31 |
| Last Modified: | 19 Apr 2023 01:13 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/88334 |
| DOI: | 10.1093/gbe/evr045 |
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