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ToolsMulvey, Michael R., Finley, Rita, Allen, Vanessa, Ang, Lei, Bekal, Sadjia, El Bailey, Sameh, Haldane, David, Hoang, Linda, Horsman, Greg, Louie, Marie, Robberts, Lourens, Wylie, John, McCracken, Elissa, Langner, Stacie, Ahmed, Rafiq, Tabor, Helen and Gilmour, Matthew (2013) Emergence of multidrug-resistant Salmonella enterica serotype 4,[5],12:i:- Involving human cases in Canada: Results from the Canadian Integrated Program on Antimicrobial Resistance Surveillance (CIPARS), 2003-10. Journal of Antimicrobial Chemotherapy, 68 (9). pp. 1982-1986. ISSN 0305-7453
Full text not available from this repository. (Request a copy)Abstract
Objectives: Over the last decade, a marked increase in Salmonella enterica serotype 4,[5],12:i:- with a core resistance to ampicillin, streptomycin, sulphonamides and tetracycline (ASSuT) has been observed in Europe. This study describes the emergence and characterization of isolates of multidrug-resistant Salmonella 4,[5],12:i:- in Canada. Methods: Human clinical isolates of Salmonella 4,[5],12:i:- were identified by provincial laboratories from 2003 to 2010. Serotyping and phage typing were performed by standardized methodologies. MIC values were determined using broth microdilution. PCR was used to determine the presence of resistance genes. Multilocus sequence typing was performed on a selected number of isolates. Results: A total of 26251 Salmonella were submitted as part of the Canadian Integrated Program on Antibiotic Resistance Surveillance (CIPARS). Of these, Salmonella 4,[5],12:i:- accounted for a total of 766 isolates (2.9%), and the number increased significantly from 42 (1.4%) in 2003 to 164 (4.8%) in 2010. The ASSuT+ phenotype was observed in 11.9% (n1/491) of Salmonella 4,[5],12:i:- isolates and increased from two isolates in 2003 to 35 isolates in 2010. Two sequence types (STs) were observed. ST34 was mainly associated with the ASSuT isolates (n1/424; 38%), which contained blaTEM, strA-strB, tet(B) and sul2. ST19 was more likely to be associated with the ACSSuT phenotype and contained blaTEM, floR, strA-strB, sul2 and tet(A) or blaPSE-1, floR, aadA2, sul1 and tet(G). Conclusions: The prevalence of Salmonella 4,[5],12:i:- has significantly increased from 2003 to 2010 and it is now the fifth most common serotype reported in Canada causing human disease. Similar antimicrobial resistance patterns, phage types and STs have been observed in Europe.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: Funding for this report was provided by the Public Health Agency of Canada and by public health programmes in the respective provinces in Canada. |
| Uncontrolled Keywords: | mdr,resistance,salmonella enterica,pharmacology,microbiology (medical),infectious diseases,pharmacology (medical),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3000/3004 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 14 Sep 2022 09:30 |
| Last Modified: | 21 Oct 2022 01:42 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/88231 |
| DOI: | 10.1093/jac/dkt149 |
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