Bacterial pathogenesis and interleukin-17: Interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection

Chamoun, Michelle N., Blumenthal, Antje, Sullivan, Matthew J. ORCID: https://orcid.org/0000-0003-2276-3132, Schembri, Mark A. and Ulett, Glen C. (2018) Bacterial pathogenesis and interleukin-17: Interconnecting mechanisms of immune regulation, host genetics, and microbial virulence that influence severity of infection. Critical Reviews in Microbiology, 44 (4). pp. 465-486. ISSN 1040-841X

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Abstract

Interleukin-17 (IL-17) is a pro-inflammatory cytokine involved in the control of many different disorders, including autoimmune, oncogenic, and diverse infectious diseases. In the context of infectious diseases, IL-17 protects the host against various classes of microorganisms but, intriguingly, can also exacerbate the severity of some infections. The regulation of IL-17 expression stems, in part, from the activity of Interleukin-23 (IL-23), which drives the maturation of different classes of IL-17-producing cells that can alter the course of infection. In this review, we analyze IL-17/IL-23 signalling in bacterial infection, and examine the interconnecting mechanisms that link immune regulation, host genetics, and microbial virulence in the context of bacterial pathogenesis. We consider the roles of IL-17 in both acute and chronic bacterial infections, with a focus on mouse models of human bacterial disease that involve infection of mucosal surfaces in the lungs, urogenital, and gastrointestinal tracts. Polymorphisms in IL-17-encoding genes in humans, which have been associated with heightened host susceptibility to some bacterial pathogens, are discussed. Finally, we examine the implications of IL-17 biology in infectious diseases for the development of novel therapeutic strategies targeted at preventing bacterial infection.

Item Type:	Article
Additional Information:	Funding Information: This work was supported by the National Medical Research Council (NHMRC; Australia) under grant number APP1084889. Publisher Copyright: © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
Uncontrolled Keywords:	bacterial pathogenesis,host–pathogen interactions,infection,innate immunity,interleukin-17,microbiology,applied microbiology and biotechnology,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2400/2404
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	12 Sep 2022 10:31
Last Modified:	23 Oct 2022 21:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/88105
DOI:	10.1080/1040841X.2018.1426556

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