Single-cell microfluidic platform to study anaerobic bacteria

Song, Yanqing, Glidle, Andrew, Quince, Christopher, Collins, Gavin, Sloan, William and Yin, Huabing (2019) Single-cell microfluidic platform to study anaerobic bacteria. In: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 . Chemical and Biological Microsystems Society, CHE, pp. 508-509. ISBN 9781733419000

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Abstract

We present a novel, anaerobic microfluidic system, for real-time monitoring of strictly anaerobic bacteria with single-cell resolution. Chemotactic responses of a cellulolytic bacterium Clostridium Cellulolyticum towards cellobiose were characterized using a gradient microfluidic device. The degradation of microcrystalline cellulose by C. cellulolyticum was observed in parallel microfluidic channels, suggesting that chemotaxis may play a key role in cellulose degradation by anaerobic digesters. These results demonstrate that microfluidics has great potential to study anaerobic microbial communities.

Item Type: Book Section
Additional Information: Funding Information: This study was supported by EPSRC (EP/K038885/1) and NERC (NE/S008721/1) grants. Publisher Copyright: © 2019 CBMS-0001.
Uncontrolled Keywords: anaerobic bacteria,cellulose,chemotaxis,microfluidics,single-cell assay,bioengineering,chemical engineering (miscellaneous) ,/dk/atira/pure/subjectarea/asjc/1500/1502
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 08 Sep 2022 13:31
Last Modified: 22 Sep 2022 23:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/87974
DOI:

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