Single-cell microfluidic platform to study anaerobic bacteria

Song, Yanqing, Glidle, Andrew, Quince, Christopher, Collins, Gavin, Sloan, William and Yin, Huabing (2019) Single-cell microfluidic platform to study anaerobic bacteria. In: 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019. 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 . Chemical and Biological Microsystems Society, CHE, pp. 508-509. ISBN 9781733419000

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Abstract

We present a novel, anaerobic microfluidic system, for real-time monitoring of strictly anaerobic bacteria with single-cell resolution. Chemotactic responses of a cellulolytic bacterium Clostridium Cellulolyticum towards cellobiose were characterized using a gradient microfluidic device. The degradation of microcrystalline cellulose by C. cellulolyticum was observed in parallel microfluidic channels, suggesting that chemotaxis may play a key role in cellulose degradation by anaerobic digesters. These results demonstrate that microfluidics has great potential to study anaerobic microbial communities.

Item Type:	Book Section
Additional Information:	Funding Information: This study was supported by EPSRC (EP/K038885/1) and NERC (NE/S008721/1) grants. Publisher Copyright: © 2019 CBMS-0001.
Uncontrolled Keywords:	anaerobic bacteria,cellulose,chemotaxis,microfluidics,single-cell assay,bioengineering,chemical engineering (miscellaneous) ,/dk/atira/pure/subjectarea/asjc/1500/1502
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Sep 2022 13:31
Last Modified:	20 Oct 2022 23:50
URI:	https://ueaeprints.uea.ac.uk/id/eprint/87974
DOI:

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