Ku complex controls the replication time of DNA in telomere regions

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Cosgrove, Andrew J., Nieduszynski, Conrad A. ORCID: https://orcid.org/0000-0003-2001-076X and Donaldson, Anne D. (2002) Ku complex controls the replication time of DNA in telomere regions. Genes and Development, 16 (19). pp. 2485-2490. ISSN 0890-9369

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Abstract

We have investigated whether the Ku complex is involved in regulating DNA replication in the yeast Saccharomyces cerevisiae. We find that Ku proteins control the replication time of telomeric regions; replication origins located close to telomeres or within subtelomeric repeat sequences normally initiate late, but are activated much earlier in mutants lacking Ku function. In contrast, origins distant from telomeres initiate replication at the normal time. Ku is one of the first components identified as important for replication timing, and specification of the replication time of chromosome ends by Ku is consistent with its role in maintaining telomere localization.

Item Type:	Article
Uncontrolled Keywords:	ku,origin,replication,saccharomyces cerevisiae,telomere,genetics,developmental biology ,/dk/atira/pure/subjectarea/asjc/1300/1311
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	08 Sep 2022 08:31
Last Modified:	21 Oct 2022 01:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/87901
DOI:	10.1101/gad.231602

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