Magnetic resonance imaging-based compartmentation and its application to measuring metabolite concentrations in the frontal lobe

Brooks, Jonathan C.W., Roberts, Neil, Kemp, Graham J., Martin, Peter A. and Whitehouse, Graham H. (1999) Magnetic resonance imaging-based compartmentation and its application to measuring metabolite concentrations in the frontal lobe. Magnetic Resonance in Medicine, 41 (5). pp. 883-888. ISSN 0740-3194

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Abstract

Partial volume mixing of water compartments within a spectros-copy voxel (e.g. cerebrospinal fluid within a 'brain' voxel) may, if not corrected for, lead to underestimation of brain metabolite concentrations. To correct for this source of bias, a new imaging-based method of compartmentation analysis is presented. Brain water, cerebrospinal fluid and solid matter content were obtained from proton density- and T2-weighted images of the brain and an external standard in 10 healthy young males (21 to 30 years), and results compared with a previously-described technique based on spectroscopy. Mean (SD) fractional water content (β(MR)) of the 2 x 2 x 2 cm3 voxel in the frontal lobes was 0.79 (0.03) by imaging, slightly but significantly (p = 0.03) smaller than the value of 0.83 (0.03) obtained by spectroscopy. From water-suppressed spectra recorded at five echo times, using β(MR) determined by imaging, the T2-corrected concentrations of compounds containing N- acetylaspartate, creatine, choline and myo-inositol were 10.6 (1.0), 8.0 (0.9), 1.6 (0.3) and 3.7 (0.7) mmol.l-1 of brain, respectively. Imaging- based compartmentation is a rapid and straightforward technique, and can be performed on standard MR systems.

Item Type: Article
Uncontrolled Keywords: compartmentation,frontal lobe,imaging,spectroscopy,radiology nuclear medicine and imaging ,/dk/atira/pure/subjectarea/asjc/2700/2741
Faculty \ School: Faculty of Social Sciences > School of Psychology
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 12:31
Last Modified: 06 Feb 2025 10:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/87827
DOI: 10.1002/(SICI)1522-2594(199905)41:5<883::AID-MRM5>3.0.CO;2-B

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