Magnetic resonance imaging-based compartmentation and its application to measuring metabolite concentrations in the frontal lobe

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Brooks, Jonathan C.W. ORCID: https://orcid.org/0000-0003-3335-6209, Roberts, Neil, Kemp, Graham J., Martin, Peter A. and Whitehouse, Graham H. (1999) Magnetic resonance imaging-based compartmentation and its application to measuring metabolite concentrations in the frontal lobe. Magnetic Resonance in Medicine, 41 (5). pp. 883-888. ISSN 0740-3194

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Abstract

Partial volume mixing of water compartments within a spectros-copy voxel (e.g. cerebrospinal fluid within a 'brain' voxel) may, if not corrected for, lead to underestimation of brain metabolite concentrations. To correct for this source of bias, a new imaging-based method of compartmentation analysis is presented. Brain water, cerebrospinal fluid and solid matter content were obtained from proton density- and T2-weighted images of the brain and an external standard in 10 healthy young males (21 to 30 years), and results compared with a previously-described technique based on spectroscopy. Mean (SD) fractional water content (β(MR)) of the 2 x 2 x 2 cm3 voxel in the frontal lobes was 0.79 (0.03) by imaging, slightly but significantly (p = 0.03) smaller than the value of 0.83 (0.03) obtained by spectroscopy. From water-suppressed spectra recorded at five echo times, using β(MR) determined by imaging, the T2-corrected concentrations of compounds containing N- acetylaspartate, creatine, choline and myo-inositol were 10.6 (1.0), 8.0 (0.9), 1.6 (0.3) and 3.7 (0.7) mmol.l-1 of brain, respectively. Imaging- based compartmentation is a rapid and straightforward technique, and can be performed on standard MR systems.

Item Type: Article
Uncontrolled Keywords: compartmentation,frontal lobe,imaging,spectroscopy,radiology nuclear medicine and imaging ,/dk/atira/pure/subjectarea/asjc/2700/2741
Faculty \ School: Faculty of Social Sciences > School of Psychology
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Depositing User: LivePure Connector
Date Deposited: 07 Sep 2022 12:31
Last Modified: 21 Oct 2022 01:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/87827
DOI: 10.1002/(SICI)1522-2594(199905)41:5<883::AID-MRM5>3.0.CO;2-B

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