Atoms to phenotypes: Molecular design principles of cellular energy metabolism

Singharoy, Abhishek, Maffeo, Christopher, Delgado-Magnero, Karelia H., Swainsbury, David J. K., Sener, Melih, Kleinekathöfer, Ulrich, Vant, John W., Nguyen, Jonathan, Hitchcock, Andrew, Isralewitz, Barry, Teo, Ivan, Chandler, Danielle E., Stone, John E., Phillips, James C., Pogorelov, Taras V., Mallus, M. Ilaria, Chipot, Christophe, Luthey-Schulten, Zaida, Tieleman, D. Peter, Hunter, C. Neil, Tajkhorshid, Emad, Aksimentiev, Aleksei and Schulten, Klaus (2019) Atoms to phenotypes: Molecular design principles of cellular energy metabolism. Cell, 179 (5). 1098-1111.e23. ISSN 0092-8674

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Abstract

A full atomic resolution model of an entire organelle, the photosynthetic chromatophore vesicle of a purple bacterium, is constructed and reveals how the photosynthetic apparatus is optimized for ATP production in low-light habitats.

Item Type:	Article
Additional Information:	Funding Information: A.S. acknowledges start-up award funds from Arizona State University and grants from the Research Corporation for Science Advancement and the Gordon and Betty Moore Foundation; United States , Lightworks Foundation , and Flinn Foundation . E.T., A.A., C.M., A.S., C.C., B.I., I.T., D.C., J.E.S., and J.P. acknowledge NIH grants P41-GM104601 (PI: E.T.) and NIH R01-GM067887 (PI: E.T.). A.S., C.M., Z.L.-S., and A.A. acknowledge the Center for Physics of Living Cells ( NSF PHY-1430124 ). M.S. and Z.L.-S. also acknowledge NSF funding through MCB1616790 . T.V.P. acknowledges support from the Department of Chemistry , the School of Chemical Sciences , and the Office of the Vice Chancellor for Research at the University of Illinois at Urbana-Champaign . C.C. acknowledges support from the Contrat Plan État Région (CPER) IT2MP and the European Regional Development Fund (ERDF). Work in D.P.T.’s group is supported by the Natural Sciences and Engineering Research Council (Canada) with further support from the Canada Research Chairs Program and Alberta Innovates Technology Futures . D.P.T. and K.H.D.M. acknowledge Compute Canada , funded by the Canada Foundation of Innovation and partners, for computational resources. U.K. acknowledges grant KL 1299/12-1 from the Deutsche Forschungsgemeinschaft (DFG). D.J.K.S., A.H., and C.N.H. acknowledge research grant BB/M000265/1 from the Biotechnology and Biological Sciences Research Council (UK). C.N.H. was also supported by advanced award 338895 from the European Research Council . The study was also funded by the Photosynthetic Antenna Research Center (PARC), an Energy Frontier Research Center supported by the Department of Energy , Office of Science , and Office of Basic Energy Sciences under award DE-SC0001035 (to C.N.H., K.S., and M.S.). This research used resources of the Oak Ridge Leadership Computing Facility, which is supported by the Office of Science , Department of Energy ( DE-AC05-00OR22725 ). Funding Information: A.S. acknowledges start-up award funds from Arizona State University and grants from the Research Corporation for Science Advancement and the Gordon and Betty Moore Foundation; United States, Lightworks Foundation, and Flinn Foundation. E.T. A.A. C.M. A.S. C.C. B.I. I.T. D.C. J.E.S. and J.P. acknowledge NIH grants P41-GM104601 (PI: E.T.) and NIH R01-GM067887 (PI: E.T.). A.S. C.M. Z.L.-S. and A.A. acknowledge the Center for Physics of Living Cells (NSF PHY-1430124). M.S. and Z.L.-S. also acknowledge NSF funding through MCB1616790. T.V.P. acknowledges support from the Department of Chemistry, the School of Chemical Sciences, and the Office of the Vice Chancellor for Research at the University of Illinois at Urbana-Champaign. C.C. acknowledges support from the Contrat Plan ?tat R?gion (CPER) IT2MP and the European Regional Development Fund (ERDF). Work in D.P.T.?s group is supported by the Natural Sciences and Engineering Research Council (Canada) with further support from the Canada Research Chairs Program and Alberta Innovates Technology Futures. D.P.T. and K.H.D.M. acknowledge Compute Canada, funded by the Canada Foundation of Innovation and partners, for computational resources. U.K. acknowledges grant KL 1299/12-1 from the Deutsche Forschungsgemeinschaft (DFG). D.J.K.S. A.H. and C.N.H. acknowledge research grant BB/M000265/1 from the Biotechnology and Biological Sciences Research Council (UK). C.N.H. was also supported by advanced award 338895 from the European Research Council. The study was also funded by the Photosynthetic Antenna Research Center (PARC), an Energy Frontier Research Center supported by the Department of Energy, Office of Science, and Office of Basic Energy Sciences under award DE-SC0001035 (to C.N.H. K.S. and M.S.). This research used resources of the Oak Ridge Leadership Computing Facility, which is supported by the Office of Science, Department of Energy (DE-AC05-00OR22725). Conceptualization, A.S. A.A. M.S. C.N.H. and K.S.; Methodology, A.S. M.S. C.M. A.A. U.K. C.C. D.P.T. Z.L.-S. and C.N.H.; Investigation, A.S. C.M. K.H.D.M. D.J.K.S. M.S. U.K. J.W.V. J.N. I.T. D.E.C. A.H. T.V.P. and M.I.M.; Writing ? Original Draft, A.S. A.A. K.H.D.M. M.S. C.C. Z.L.-S. E.T. and C.N.H.; Writing ? Review & Editing, J.W.V. J.N. A.S. A.A. C.C. K.H.D.M. M.S. U.K. D.P.T. E.T. D.J.K.S. and A.H.; Visualization, B.I. J.E.S. and A.S.; Funding Acquisition, A.S. E.T. Z.L.-S. A.A. and K.S.; Resources, A.S. J.C.P. J.E.S. A.A. Z.L.-S. and E.T.; Supervision, A.S. A.A. C.N.H. D.P.T. and K.S. The authors declare no competing interests. Publisher Copyright: © 2019
Uncontrolled Keywords:	bioenergetics,biological membranes,charge transport,chromatophore,integrative model,md,mitochondria,molecular dynamics simulation,optical spectroscopy,photosynthesis,biochemistry, genetics and molecular biology(all) ,/dk/atira/pure/subjectarea/asjc/1300
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Molecular Microbiology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	17 Aug 2022 12:31
Last Modified:	25 Sep 2024 16:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/87356
DOI:	10.1016/j.cell.2019.10.021

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