Renin-angiotensin-aldosterone inhibitors and COVID-19 infection

Tsampasian, Vasiliki, Corballis, Natasha and Vassiliou, Vassilios S. ORCID: (2022) Renin-angiotensin-aldosterone inhibitors and COVID-19 infection. Current Hypertension Reports, 24. 425–433. ISSN 1522-6417

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Purpose of Review: This review summarises the literature data and provides an overview of the role and impact of the use of renin–angiotensin–aldosterone system (RAAS) inhibitors in patients with coronavirus disease 2019 (COVID-19) infection. Recent Findings: The angiotensin-converting enzyme 2 (ACE2) has a key role in the regulation of the RAAS pathway, downregulating angiotensin II and attenuating inflammation, vasoconstriction and oxidative stress. Additionally, it plays an instrumental part in COVID-19 infection as it facilitates the cell entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enables its replication. The use and role of RAAS inhibitors therefore during the COVID-19 pandemic have been intensively investigated. Summary: Although it was initially assumed that RAAS inhibitors may relate to worse clinical outcomes and severe disease, data from large studies and meta-analyses demonstrated that they do not have an adverse impact on clinical outcomes or prognosis. On the contrary, some experimental and retrospective observational cohort studies showed a potential protective mechanism, although this effect remains to be seen in large clinical trials.

Item Type: Article
Uncontrolled Keywords: angiotensin-converting enzyme 2 (ace2),coronavirus disease 2019 (covid-19),renin–angiotensin–aldosterone system (raas),severe acute respiratory syndrome coronavirus 2 (sars-cov-2),internal medicine ,/dk/atira/pure/subjectarea/asjc/2700/2724
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 02 Aug 2022 10:30
Last Modified: 19 Oct 2023 03:21
DOI: 10.1007/s11906-022-01207-3


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