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Tsampasian, Vasiliki, Corballis, Natasha and Vassiliou, Vassilios S. 
ORCID: https://orcid.org/0000-0002-4005-7752
(2022)
Renin-angiotensin-aldosterone inhibitors and COVID-19 infection.
Current Hypertension Reports, 24 (10).
425–433.
ISSN 1522-6417
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Abstract
Purpose of Review: This review summarises the literature data and provides an overview of the role and impact of the use of renin–angiotensin–aldosterone system (RAAS) inhibitors in patients with coronavirus disease 2019 (COVID-19) infection. Recent Findings: The angiotensin-converting enzyme 2 (ACE2) has a key role in the regulation of the RAAS pathway, downregulating angiotensin II and attenuating inflammation, vasoconstriction and oxidative stress. Additionally, it plays an instrumental part in COVID-19 infection as it facilitates the cell entry of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and enables its replication. The use and role of RAAS inhibitors therefore during the COVID-19 pandemic have been intensively investigated. Summary: Although it was initially assumed that RAAS inhibitors may relate to worse clinical outcomes and severe disease, data from large studies and meta-analyses demonstrated that they do not have an adverse impact on clinical outcomes or prognosis. On the contrary, some experimental and retrospective observational cohort studies showed a potential protective mechanism, although this effect remains to be seen in large clinical trials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | angiotensin-converting enzyme 2 (ace2),coronavirus disease 2019 (covid-19),renin–angiotensin–aldosterone system (raas),severe acute respiratory syndrome coronavirus 2 (sars-cov-2),internal medicine ,/dk/atira/pure/subjectarea/asjc/2700/2724 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Aug 2022 10:30 |
| Last Modified: | 20 Dec 2024 01:07 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/87036 |
| DOI: | 10.1007/s11906-022-01207-3 |
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