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Kandil, Lamia Said 
ORCID: https://orcid.org/0000-0002-5414-5403, Farid, Ragwa M., ElGamal, Safaa S. and Sayed Hanafy, Amira
(2021)
Intranasal galantamine/chitosan complex nanoparticles elicit neuroprotection potentials in rat brains via antioxidant effect.
Drug Development and Industrial Pharmacy, 47 (5).
pp. 735-740.
ISSN 0363-9045
Abstract
Background: Alzheimer’s disease is a common cause of dementia in the elderly. Galantamine hydrobromide (GH) is an anti-Alzheimer cholinesterase inhibitor that has an intrinsic antioxidant effect. In a previous study, GH was complexed with chitosan to prepare intranasal GH/chitosan complex nanoparticles (CX-NP2). The nanoparticles were located in rat brains 1 h after nasal administration and showed pharmacological superiority to GH nasal solution without showing histopathological toxicity. Objective: This study aimed to investigate whether the long-term administration of CX-NP2 leads to biochemical toxicity in rat brains compared to GH nasal solution. Methods: CX-NP2 dispersion and GH solution were administrated intranasally to male Wistar rats for 30 days (3 mg/kg/day). Malondialdehyde (MDA), lipid peroxidation marker, glutathione (GSH), superoxide dismutase (SOD) activity and tumor necrosis factor-α (TNF-α) were assessed in the brain extracts in all groups. Results: There was statistically insignificant difference between the CX-NP2 and GH nasal solution treated groups in all biochemical toxicity parameters assessed. Interestingly, MDA and TNF-α levels in the CX-NP2-treated group significantly decreased compared to the control group. Also, GSH level and SOD activity were significantly enhanced in CX-NP2 treated group compared to the control group. Conclusions: CX-NP2 did not induce a statistically significant oxidative stress or neuroinflammation in rat brains after 30-day treatment, they rather elicited neuroprotective potentials.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | alzheimer's disease,brain targeting,chitosan nanoparticles,nanotoxicity,nasal drug delivery,pharmacology,pharmaceutical science,drug discovery,organic chemistry ,/dk/atira/pure/subjectarea/asjc/3000/3004 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Biosciences Teaching and Education Research |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 21 Jul 2022 11:38 |
| Last Modified: | 19 Aug 2023 00:48 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/86793 |
| DOI: | 10.1080/03639045.2021.1934861 |
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