Kelemen, Gabriella H., Zalacain, Magdalena, Culebras, Esther, Seno, Eugene T. and Cundliffe, Eric (1994) Transcriptional attenuation control of the tylosin‐resistance gene tlrA in Streptomyces fradiae. Molecular Microbiology, 14 (4). pp. 833-842. ISSN 0950-382X
Full text not available from this repository. (Request a copy)Abstract
The tylosin producer Streptomyces fradiae contains four known resistance genes, two of which (tlrA and tlrD) encode methyltransferases that act on ribosomal RNA at a common site. Expression of tlrA is regulated via transcriptional attenuation. A short transcript, only 411 nucleotides long, terminates 27 nucleotides into the methylase‐coding sequence in the uninduced state. Induction of tlrA is proposed to involve a ribosome‐mediated conformational change within the mRNA leader that allows transcription to continue beyond the attenuation site, resulting in a transcript about 1450 nucleotides long. Transplantation of tlrD and/or tlrA into Streptomyces albus revealed that the induction specificity of tlrA depends upon the state of the ribosomes and is significantly altered in strains also expressing tlrD.
Item Type: | Article |
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Uncontrolled Keywords: | microbiology,molecular biology ,/dk/atira/pure/subjectarea/asjc/2400/2404 |
Faculty \ School: | Faculty of Science > School of Biological Sciences |
UEA Research Groups: | Faculty of Science > Research Groups > Molecular Microbiology |
Related URLs: | |
Depositing User: | LivePure Connector |
Date Deposited: | 19 Jul 2022 16:30 |
Last Modified: | 23 Oct 2022 04:04 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/86644 |
DOI: | 10.1111/j.1365-2958.1994.tb01319.x |
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