Deletion of DNA lying close to the glkA locus induces ectopic sporulation in Streptomyces coelicolor A3(2)

Kelemen, Gabriella H., Plaskitt, Kitty A., Lewis, Cinzia G., Findlay, Kim C. and Buttner, Mark J. (1995) Deletion of DNA lying close to the glkA locus induces ectopic sporulation in Streptomyces coelicolor A3(2). Molecular Microbiology, 17 (2). pp. 221-230. ISSN 0950-382X

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Abstract

Streptomyces coelicolor A3(2) J1668 sporulated ectopically in the substrate hyphae (the Esp phenotype) with the same time course as sporulation in the aerial hyphae. Examination of related strains implied that the Esp phenotype was caused by the deletion of DNA that lies close to, but is distinct from, the glucose kinase gene (glkA). Co‐transduction of the Esp phenotype with the deletion present in J1668 confirmed this hypothesis. The size of the deletion was found to be 7.4 kb. Construction of a strain carrying both the J1668 deletion and a whiG mutation demonstrated that the Esp phenotype depends on at least one of the genes required for the differentiation of aerial hyphae into spores.

Item Type:	Article
Uncontrolled Keywords:	microbiology,molecular biology ,/dk/atira/pure/subjectarea/asjc/2400/2404
Faculty \ School:	Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Groups > Molecular Microbiology
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	19 Jul 2022 16:30
Last Modified:	23 Oct 2022 04:04
URI:	https://ueaeprints.uea.ac.uk/id/eprint/86643
DOI:	10.1111/j.1365-2958.1995.mmi_17020221.x

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