Characterization of the mouse met proto-oncogene

Chan, A. M.L., King, H. W.S., Deakin, E. A., Tempest, P. R., Hilkens, J., Kroezen, V., Edwards, D. R. ORCID: https://orcid.org/0000-0002-3292-2064, Wills, A. J., Brookes, P. and Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 (1988) Characterization of the mouse met proto-oncogene. Oncogene, 2 (6). pp. 593-599. ISSN 0950-9232

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Abstract

The DNA sequence of cDNA clones prepared from transcripts of the mouse met proto-oncogene reveals that the mouse met gene encodes a 1380 amino acid protein with the characteristics of a growth factor receptor. This protein can be divided into several putative domains, including an intracellular protein tyrosine kinase domain, a transmembrane domain and a 929 amino acid extracellular domain, possessing a potential proteolytic cleavage site with the sequence Lys-Arg-Arg-Lys-Arg-Ser. To gain additional insights into the function of the met protein we have examined the level of met transcripts in tissues of the late-gestation mouse conceptus. Transcription of met was observed in most of the tissues analysed, but the highest levels of met mRNA were detected in the yolk sac, amnion and kidney; no transcripts were detectable in the calvaria. Chromosomal localization using a series of mouse-hamster hybrid cell lines has demonstrated that met is located on mouse chromosome 6.

Item Type: Article
Uncontrolled Keywords: molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 17:31
Last Modified: 01 Aug 2022 11:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/86552
DOI:

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