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ToolsChan, A. M.L., King, H. W.S., Deakin, E. A., Tempest, P. R., Hilkens, J., Kroezen, V., Edwards, D. R., Wills, A. J., Brookes, P. and Cooper, C. S. (1988) Characterization of the mouse met proto-oncogene. Oncogene, 2 (6). pp. 593-599. ISSN 0950-9232
Full text not available from this repository. (Request a copy)Abstract
The DNA sequence of cDNA clones prepared from transcripts of the mouse met proto-oncogene reveals that the mouse met gene encodes a 1380 amino acid protein with the characteristics of a growth factor receptor. This protein can be divided into several putative domains, including an intracellular protein tyrosine kinase domain, a transmembrane domain and a 929 amino acid extracellular domain, possessing a potential proteolytic cleavage site with the sequence Lys-Arg-Arg-Lys-Arg-Ser. To gain additional insights into the function of the met protein we have examined the level of met transcripts in tissues of the late-gestation mouse conceptus. Transcription of met was observed in most of the tissues analysed, but the highest levels of met mRNA were detected in the yolk sac, amnion and kidney; no transcripts were detectable in the calvaria. Chromosomal localization using a series of mouse-hamster hybrid cell lines has demonstrated that met is located on mouse chromosome 6.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 18 Jul 2022 17:31 |
| Last Modified: | 06 Feb 2025 10:44 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/86552 |
| DOI: |
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