No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families

Warren, W., Eeles, R. A., Ponder, B. A.J., Easton, D. F., Averill, D., Ponder, M. A., Anderson, K., Evans, A. M., DeMars, R., Love, R., Dundas, S., Stratton, M. R., Trowbridge, P., Cooper, C. S. ORCID: https://orcid.org/0000-0003-2013-8042 and Peto, J. (1992) No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families. Oncogene, 7 (5). pp. 1043-1046. ISSN 0950-9232

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Abstract

Recent studies have demonstrated that families with the Li-Fraumeni syndrome carry inherited point mutations of the p53 gene. In the present study 25 families with strong histories of breast cancer were screened for the presence of such mutations. Polymerase chain reaction products of exons 5-9 of the p53 gene were examined by single-stranded conformational polymorphism analysis and, in addition, exon 7 was further screened by direct sequencing. No mutations were detected in constitutive DNA by either method. These results indicate that familial breast cancer does not usually result from germline point mutations in the p53 gene.

Item Type: Article
Uncontrolled Keywords: molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 17:30
Last Modified: 25 Jul 2022 00:25
URI: https://ueaeprints.uea.ac.uk/id/eprint/86525
DOI:

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