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Warren, W., Eeles, R. A., Ponder, B. A.J., Easton, D. F., Averill, D., Ponder, M. A., Anderson, K., Evans, A. M., DeMars, R., Love, R., Dundas, S., Stratton, M. R., Trowbridge, P., Cooper, C. S. 
ORCID: https://orcid.org/0000-0003-2013-8042 and Peto, J.
(1992)
No evidence for germline mutations in exons 5-9 of the p53 gene in 25 breast cancer families.
Oncogene, 7 (5).
pp. 1043-1046.
ISSN 0950-9232
Abstract
Recent studies have demonstrated that families with the Li-Fraumeni syndrome carry inherited point mutations of the p53 gene. In the present study 25 families with strong histories of breast cancer were screened for the presence of such mutations. Polymerase chain reaction products of exons 5-9 of the p53 gene were examined by single-stranded conformational polymorphism analysis and, in addition, exon 7 was further screened by direct sequencing. No mutations were detected in constitutive DNA by either method. These results indicate that familial breast cancer does not usually result from germline point mutations in the p53 gene.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 18 Jul 2022 17:30 |
| Last Modified: | 23 Oct 2022 04:02 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/86525 |
| DOI: |
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