Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma

Clark, Jeremy, Benjamin, Harry, Gill, Sandra, Sidhar, Sanjiu, Goodwin, Graham, Crew, Jayne, Gusterson, Barry A., Shipley, Janet and Cooper, Colin S. ORCID: https://orcid.org/0000-0003-2013-8042 (1996) Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma. Oncogene, 12 (2). pp. 229-235. ISSN 0950-9232

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Abstract

The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma, In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-31, in a skeletal myxoid chondrosarcoma. CHN appears to be the human homologue of the rat gene NOR1, which was recently identified as a sequence overexpressed in rat brain cells undergoing apoptosis, Our results also indicate that the chimaeric EWS-CHN gene encodes a EWS-CHN fusion protein in which the C-terminal RNA-binding domain of EWS is replaced by the entire CHN protein, comprising a long N-terminal domain, a central DNA binding domain and a C-terminal ligand-binding/dimerisation domain.

Item Type: Article
Uncontrolled Keywords: chn oncogene,chondrosarcoma,thyroid receptor,molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 18 Jul 2022 16:31
Last Modified: 12 Aug 2022 05:43
URI: https://ueaeprints.uea.ac.uk/id/eprint/86507
DOI:

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