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Clark, Jeremy, Benjamin, Harry, Gill, Sandra, Sidhar, Sanjiu, Goodwin, Graham, Crew, Jayne, Gusterson, Barry A., Shipley, Janet and Cooper, Colin S. 
ORCID: https://orcid.org/0000-0003-2013-8042
(1996)
Fusion of the EWS gene to CHN, a member of the steroid/thyroid receptor gene superfamily, in a human myxoid chondrosarcoma.
Oncogene, 12 (2).
pp. 229-235.
ISSN 0950-9232
Abstract
The specific chromosomal translocation t(9;22)(q22-31;q11-12) has been observed in the myxoid variant of human chondrosarcoma, In agreement with this observation we report that the EWS gene located at chromosome band 22q12 becomes fused to CHN, a member of the steroid/thyroid receptor gene superfamily located at 9q22-31, in a skeletal myxoid chondrosarcoma. CHN appears to be the human homologue of the rat gene NOR1, which was recently identified as a sequence overexpressed in rat brain cells undergoing apoptosis, Our results also indicate that the chimaeric EWS-CHN gene encodes a EWS-CHN fusion protein in which the C-terminal RNA-binding domain of EWS is replaced by the entire CHN protein, comprising a long N-terminal domain, a central DNA binding domain and a C-terminal ligand-binding/dimerisation domain.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chn oncogene,chondrosarcoma,thyroid receptor,molecular biology,genetics,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 18 Jul 2022 16:31 |
| Last Modified: | 23 Oct 2022 04:01 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/86507 |
| DOI: |
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