Oligodendrocyte precursor (O-2A progenitor cell) migration; A model system for the study of cell migration in the developing central nervous system

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Kiernan, B. W. and ffrench-Constant, C. ORCID: https://orcid.org/0000-0002-5621-3377 (1993) Oligodendrocyte precursor (O-2A progenitor cell) migration; A model system for the study of cell migration in the developing central nervous system. Development, 119 (SUPPL.). pp. 219-225. ISSN 0950-1991

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Abstract

Cell migration plays an important role in the development of complex multicellular organisms. The molecular mechanisms that regulate this migration are therefore of great interest. Unfortunately, however, analysis of cell migration in vertebrates is hampered by the inaccessability of the cells and the difficulty of manipulating their environment within the embryo. This review focusses on one particular migratory cell population, the oligodendrocyte precursor cell or O-2A progenitor cell, that gives rise to the myelin-forming oligodendrocytes within the CNS. These cells migrate extensively during normal development. They can be purified and grown in large numbers in cell culture, so allowing the use of reductionist approaches using cell and molecular biology techniques. Moreover, cultured cells will migrate within the CNS following transplantation. As a result, the migration of these cells in vivo can be analysed following manipulation in vitro. Taken together, we believe that the different properties of these cells makes them excellent candidates for studies addressing the control of cell migration in the developing nervous system.

Item Type: Article
Uncontrolled Keywords: cell adhesion,cell migration,extracellular matrix,lamina cribrosa,o-2a progenitor cell,oligodendrocyte,tenascin,molecular biology,developmental biology ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 16 Jul 2022 17:30
Last Modified: 23 Oct 2022 03:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/86395
DOI:

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