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Hidalgo, Alicia and Ffrench-Constant, Charles 
ORCID: https://orcid.org/0000-0002-5621-3377
(2003)
The control of cell number during central nervous system development in flies and mice.
Mechanisms of Development, 120 (11).
pp. 1311-1325.
ISSN 0925-4773
Abstract
Growth is confined within a size that is normal for each species, revealing that somehow an organism 'knows' when this size has been reached. Within a species, growth is also variable, but despite this, proportion and structure are maintained. Perhaps, the key element in the control of size is the control of cell number. Here we review current knowledge on the mechanisms controlling cell number in the nervous system of vertebrates and flies. During growth, clonal expansion is confined, the number of progeny cells is balanced through the control of cell survival and cell proliferation and excess cells are eliminated by apoptosis. Simultaneously, organ architecture emerges and as neurons become active they also influence growth. The interactive control of cell number provides developmental plasticity to nervous system development. Many findings are common between flies and mice, other aspects have been studied more in one organism than the other and there are also aspects that are unique to either organism. Although cell number control has long been studied in the nervous system, analogous mechanisms are likely to operate during the growth of other organs and organisms.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: We are grateful to Martin Raff for long term inspiration and for encouraging the concept of this review. A.H.'s work is funded by an MRC CEG, Wellcome Trust CDF and EMBO YIP; C.ff-C. holds a Wellcome Trust Research Leave Fellowship for clinical academics and his work is funded by the Wellcome Trust, the Multiple Sclerosis Society of Great Britain and Northern Ireland and by a FP5 grant of the EU. |
| Uncontrolled Keywords: | cell death,cell number,central nervous system,growth,size,stem cells,embryology,developmental biology ,/dk/atira/pure/subjectarea/asjc/2700/2710 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 16 Jul 2022 12:30 |
| Last Modified: | 23 Oct 2022 03:57 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/86345 |
| DOI: | 10.1016/j.mod.2003.06.004 |
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