Integrin-growth factor interactions as regulators of oligodendroglial development and function

Baron, Wia, Colognato, Holly and ffrench-Constant, Charles ORCID: https://orcid.org/0000-0002-5621-3377 (2005) Integrin-growth factor interactions as regulators of oligodendroglial development and function. Glia, 49 (4). pp. 467-479. ISSN 0894-1491

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Abstract

Central nervous system (CNS) development requires mechanisms for the regulation of cell number. Although growth factors are essential determinants of the proliferation and apoptosis that determine final numbers, the long-range nature of signals from diffusible growth factors makes them insufficient for the provision of the precise and localized signals required. Integration of integrin and growth factor receptor signaling in controlling cell behavior has been an important theme of research over the past several years. The focus of this review is on the mechanisms by which integrin-growth factor interactions regulate the development of oligodendrocytes and provide a mechanism for controlling, both in space and in time, oligodendrocyte numbers in the developing CNS.

Item Type:	Article
Additional Information:	An erratum is available for this article. It corrects the article type (from Original Article to Review Article) and corrects the spelling of the third author's name (the correct spelling is given here). See: https://onlinelibrary.wiley.com/doi/10.1002/glia.20238
Uncontrolled Keywords:	neurology,cellular and molecular neuroscience ,/dk/atira/pure/subjectarea/asjc/2800/2808
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	16 Jul 2022 11:31
Last Modified:	21 Jul 2024 01:20
URI:	https://ueaeprints.uea.ac.uk/id/eprint/86330
DOI:	10.1002/glia.20132

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