Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys

Sprooten, E., Sussmann, J. E., Moorhead, T. W., Whalley, H. C., Ffrench-Constant, C. ORCID: https://orcid.org/0000-0002-5621-3377, Blumberg, H. P., Bastin, M. E., Hall, J., Lawrie, S. M. and McIntosh, A. M. (2011) Reduced white matter integrity in healthy individuals carrying the A-allele at DISC1 Ser704Cys. Molecular Psychiatry, 16 (7). ISSN 1359-4184

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Abstract

Association of fractional anisotropy (FA) with the DISC1 Ser704Cys allele in healthy individuals. Tract-based spatial statistics were applied, followed by voxel-wise comparisons using ‘randomise’ in FSL (http://www.fmrib.ox.ac.uk/fsl). Voxels with significantly higher FA in TT homozygotes compared with AA homozygotes are shown in red–yellow (PFWE<0.05). There were no voxels in which the AA group had significantly higher FA. The images are shown in radiological convention. For more info on this topic, please refer to the article by Sprooten et al. on pages 688–689.

Item Type:	Article
Uncontrolled Keywords:	molecular biology,psychiatry and mental health,cellular and molecular neuroscience,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1312
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	16 Jul 2022 00:27
Last Modified:	06 Jan 2023 16:33
URI:	https://ueaeprints.uea.ac.uk/id/eprint/86282
DOI:	10.1038/mp.2011.69

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