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Chandran, Jayanth S., Kazanis, Ilias, Clapcote, Steven J., Ogawa, Fumiaki, Millar, J. Kirsty, Porteous, David J. and ffrench-Constant, Charles 
ORCID: https://orcid.org/0000-0002-5621-3377
(2014)
Disc1 variation leads to specific alterations in adult neurogenesis.
PLoS One, 9 (10).
ISSN 1932-6203
Abstract
Disrupted in schizophrenia 1 (DISC1) is a risk factor for a spectrum of neuropsychiatric illnesses including schizophrenia, bipolar disorder, and major depressive disorder. Here we use two missense Disc1 mouse mutants, described previously with distinct behavioural phenotypes, to demonstrate that Disc1 variation exerts differing effects on the formation of newly generated neurons in the adult hippocampus. Disc1 mice carrying a homozygous Q31L mutation, and displaying depressive-like phenotypes, have fewer proliferating cells while Disc1 mice with a homozygous L100P mutation that induces schizophrenia-like phenotypes, show changes in the generation, placement and maturation of newly generated neurons in the hippocampal dentate gyrus. Our results demonstrate Disc1 allele specific effects in the adult hippocampus, and suggest that the divergence in behavioural phenotypes may in part stem from changes in specific cell populations in the brain.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: CFFC is supported by a grant from the Wellcome Trust, which also provides strategic support (ISSF) for DP. |
| Uncontrolled Keywords: | biochemistry, genetics and molecular biology(all),agricultural and biological sciences(all),general ,/dk/atira/pure/subjectarea/asjc/1300 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Jul 2022 22:30 |
| Last Modified: | 25 Sep 2024 16:29 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/86259 |
| DOI: | 10.1371/journal.pone.0108088 |
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