Goddard, Alan D., Stevens, Julie M., Rao, Feng, Mavridou, Despoina A.I., Chan, Weelee, Richardson, David J. ORCID: https://orcid.org/0000-0002-6847-1832, Allen, James W.A. and Ferguson, Stuart J.
(2011)
c-Type cytochrome biogenesis can occur via a natural Ccm system lacking CcmH, CcmG, and the heme-binding histidine of CcmE (Journal of Biological Chemistry (2010) 285, (22882-22889)).
Journal of Biological Chemistry, 286 (33).
p. 29442.
ISSN 0021-9258
Abstract
The Ccm cytochrome c maturation System I catalyzes covalent attachment of heme to apocytochromes c in many bacterial species and some mitochondria. A covalent, but transient, bond between heme and a conserved histidine in CcmE along with an interaction between CcmH and the apocytochrome have been previously indicated as core aspects of the Ccm system. Here, we show that in the Ccm system from Desulfovibrio desulfuricans, no CcmH is required, and the holo-CcmE covalent bond occurs via a cysteine residue. These observations call for reconsideration of the accepted models of System I-mediated c-type cytochrome biogenesis.
Item Type: | Article |
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Uncontrolled Keywords: | biochemistry,molecular biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
Faculty \ School: | Faculty of Science > School of Biological Sciences |
Related URLs: | |
Depositing User: | LivePure Connector |
Date Deposited: | 14 Jul 2022 16:30 |
Last Modified: | 23 Oct 2022 03:52 |
URI: | https://ueaeprints.uea.ac.uk/id/eprint/86118 |
DOI: | 10.1074/jbc.A110.133421 |
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