Synthesis of L-trehalose and observations on isomer and by-product formation

Haines, Alan H. (2003) Synthesis of L-trehalose and observations on isomer and by-product formation. Carbohydrate Research, 338 (9). pp. 813-818. ISSN 0008-6215

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Abstract

With a view to gaining evidence on the mechanism by which D-trehalose is able to stabilise biomolecules towards dehydration (anhydrobiosis) and heat, L-trehalose has been prepared in order to allow comparative studies to be made. Little change can be induced in the ratio of the α,α-, α,β-, β,β-1,1′-stereoisomers of the disaccharide formed from 2,3,4,6-tetra-O-benzyl-L-glucose by using different reaction procedures and by varying the reaction conditions. Benzyl 2,3,4,6-tetra-O-benzyl α- and β-L-glucopyranoside are by-products in the trimethylsilyl trifluoromethanesulphonate mediated formation of the 1,1′-linked disaccharides.

Item Type:	Article
Uncontrolled Keywords:	1,1′-linked disaccharide,anhydrobiosis,biostabilisation,l-trehalose,analytical chemistry,biochemistry,organic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1602
Faculty \ School:	Faculty of Science > School of Chemistry (former - to 2024)
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	14 Jul 2022 12:30
Last Modified:	25 Sep 2024 16:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/86108
DOI:	10.1016/S0008-6215(03)00043-0

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