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Wright, Adam J., McMartin, Fiona J., Dyer, Liam G., Sayer, Lloyd H., Bulman Page, Philip C. and Stephenson, G. Richard 
ORCID: https://orcid.org/0000-0003-1487-9178
(2022)
Planar chiral pseudo-isocoumarins by copper catalysed desymmetrisation.
European Journal of Inorganic Chemistry, 2022 (12).
ISSN 1434-1948
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Abstract
A new copper catalysed desymmetrisation reaction of bisalkynyl ferrocenecarboxylic acids results in the first asymmetric synthesis of planar chiral pseudo-isocoumarins in up to 64 % enantiomeric excess and up to 99 % yield. The absolute configuration of the chiral heterocycles is proven by chemical correlation and circular dichroism spectroscopy, opening the way for the rational extension of this method to produce bioactive isocoumarin-fused ferrocene derivatives.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | asymmetric catalysis,asymmetric synthesis,chirality,circular dichroism,metallocenes,inorganic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1604 |
| Faculty \ School: | Faculty of Science > School of Chemistry (former - to 2024) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 21 Apr 2022 14:30 |
| Last Modified: | 01 Oct 2024 01:53 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/84713 |
| DOI: | 10.1002/ejic.202100841 |
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