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Leighton, Paul, Chalmers, Joanne R., Batchelor, Jonathan M., Rogers, Andy, Perways, Akram, Haines, Rachel H., Meakin, Garry D., White, Jennifer, Ravenscroft, Jane C., Sach, Tracey H. 
ORCID: https://orcid.org/0000-0002-8098-9220, Santer, Miriam, Whitton, Maxine E., Eleftheriadou, Viktoria and Thomas, Kim S.
(2022)
Prescribing and using vitiligo treatments: Lessons from a nested process evaluation within the HI-Light vitiligo randomised controlled trial.
Clinical and Experimental Dermatology, 47 (8).
pp. 1480-1489.
ISSN 0307-6938
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Abstract
Background: The HI-Light Trial demonstrated that for active, limited vitiligo, combination treatment with potent topical corticosteroid (TCS) and handheld narrowband ultraviolet B offers a better treatment response than potent TCS alone. However, it is unclear how to implement these findings. Aim: We sought to answer three questions: (i) Can combination treatment be used safely and effectively by people with vitiligo?; (ii) Should combination treatment be made available as routine clinical care?; and (iii) Can combination treatment be integrated within current healthcare provision?. Methods: This was a mixed-methods process evaluation, including semi-structured interviews with a purposive sample of trial participants, structured interviews with commissioners, and an online survey and focus groups with trial staff. Transcripts were coded by framework analysis, with thematic development by multiple researchers. Results: Participants found individual treatments easy to use, but the combination treatment was complicated and required nurse support. Both participants and site investigators felt that combination treatment should be made available, although commissioners were less certain. There was support for the development of services offering combination treatment, although this might not be prioritized above treatment for other conditions. A ‘mixed economy’ model was suggested, involving patients purchasing their own devices, although concerns regarding the safe use of treatments mean that training, monitoring and ongoing support are essential. The need for medical physics support may mean that a regional service is more practical. Conclusion: Combination treatment should be made available for people seeking treatment for vitiligo, but services require partnership with medical physics and ongoing training and support for patients.
| Item Type: | Article |
|---|---|
| Additional Information: | Research Funding: Health Technology Assessment Programme. Grant Number: HTA Project Reference 12/24/02 |
| Uncontrolled Keywords: | dermatology ,/dk/atira/pure/subjectarea/asjc/2700/2708 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 31 Mar 2022 13:30 |
| Last Modified: | 23 Oct 2022 03:41 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/84402 |
| DOI: | 10.1111/ced.15193 |
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